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Pre-clinical evaluation of a 3-nitro-1,2,4-triazole analogue of [18F]FMISO as hypoxia-selective tracer for PET.

Abstract:

Hypoxia in solid tumours is associated with the promotion of various metabolic mechanisms and induces resistance to radio- and chemotherapy. Non-invasive positron emission tomography (PET) or single photon emission computed tomography by use of selective biomarkers has emerged as valuable tools for the detection of hypoxic areas within tumours so treatment can be modified accordingly. The aim of this investigation was to evaluate [(18)F]3-NTR, a 3-nitro-1,2,4-triazole analogue (N(1) substitut...

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Publication status:
Published

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Journal:
Nuclear medicine and biology
Volume:
37
Issue:
5
Pages:
565-575
Publication date:
2010-07-05
DOI:
EISSN:
1872-9614
ISSN:
0969-8051
URN:
uuid:45d89e7c-45da-43ac-9968-b4d5981846a0
Source identifiers:
65268
Local pid:
pubs:65268

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