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Journal article

Chromatin structure is implicated in "late" elongation checkpoints on the U2 snRNA and beta-actin genes.

Abstract:

The negative elongation factor NELF is a key component of an early elongation checkpoint generally located within 100 bp of the transcription start site of protein-coding genes. Negotiation of this checkpoint and conversion to productive elongation require phosphorylation of the carboxy-terminal domain of RNA polymerase II (pol II), NELF, and DRB sensitivity-inducing factor (DSIF) by positive transcription elongation factor b (P-TEFb). P-TEFb is dispensable for transcription of the noncoding ...

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Publication status:
Published

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Publisher copy:
10.1128/mcb.00189-09

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Molecular and cellular biology
Volume:
29
Issue:
14
Pages:
4002-4013
Publication date:
2009-07-01
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
Source identifiers:
24280

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