Cell cycle regulation of central spindle assembly.

Journal article

The bipolar mitotic spindle is responsible for segregating sister chromatids at anaphase. Microtubule motor proteins generate spindle bipolarity and enable the spindle to perform mechanical work. A major change in spindle architecture occurs at anaphase onset when central spindle assembly begins. This structure regulates the initiation of cytokinesis and is essential for its completion. Central spindle assembly requires the centralspindlin complex composed of the Caenorhabditis elegans ZEN-4 ...

Expand abstract

Authors: Mishima, M; Pavicic, V; Grüneberg, U; Nigg, E; Glotzer, M

• Journal: Nature
• Volume: 430
• Issue: 7002
• Pages: 908-913
• Publication date: 2004-08-01
• DOI: 10.1038/nature02767
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Adenosine Triphosphatases; Protein Binding; Cell Cycle; Tubulin; Hela Cells; Animals; Anaphase; Molecular Motor Proteins; Chromosome Segregation; Protein Structure, Tertiary; Cyclin B; Microtubules; Microtubule-Associated Proteins; Mitotic Spindle Apparatus; Chromosomes; Humans; CDC2 Protein Kinase; Molecular Sequence Data; Caenorhabditis elegans Proteins; Phosphoprotein Phosphatases; Time Factors; Kinesin; Phosphorylation; Caenorhabditis elegans; Conserved Sequence; Amino Acid Sequence