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Cell cycle regulation of central spindle assembly.

Abstract:

The bipolar mitotic spindle is responsible for segregating sister chromatids at anaphase. Microtubule motor proteins generate spindle bipolarity and enable the spindle to perform mechanical work. A major change in spindle architecture occurs at anaphase onset when central spindle assembly begins. This structure regulates the initiation of cytokinesis and is essential for its completion. Central spindle assembly requires the centralspindlin complex composed of the Caenorhabditis elegans ZEN-4 ...

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Publisher copy:
10.1038/nature02767

Authors


Mishima, M More by this author
Pavicic, V More by this author
Grüneberg, U More by this author
Glotzer, M More by this author
Journal:
Nature
Volume:
430
Issue:
7002
Pages:
908-913
Publication date:
2004-08-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:45b10351-9f27-4f42-bbc2-231dd31dce8d
Source identifiers:
196723
Local pid:
pubs:196723

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