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Cavitation-enhanced delivery of a self-amplifying oncolytic adenovirus for tumour-selective cancer therapy.

Abstract:

Unlike conventional gene therapy, oncolytic adenoviruses selectively infect and replicate within cancer cells, potentially enabling systemically administered yet highly targeted self-amplifying cancer therapy. Until recently, therapeutic efficacy was hindered by limited extravasation of the virus to poorly vascularized tumour regions and by liver toxicity beyond a certain dose. In the present work, co-injection of the virus with contrast agent microbubbles (SonoVue) and exposure of the tumour...

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Publisher copy:
10.1121/1.4708112

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Engineering Science
Seymour, LW More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Engineering Science
Volume:
131
Issue:
4
Pages:
3246
Publication date:
2012-04-05
DOI:
EISSN:
1520-8524
ISSN:
0001-4966
URN:
uuid:45b0f55f-ee25-43d5-b4cd-0990191c1bd3
Source identifiers:
325171
Local pid:
pubs:325171

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