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Journal article

Creation of an α-mannosynthase from a broad glycosidase scaffold.

Abstract:
α-Mannosides made easy: Mutation of a family-GH31 α-glucosidase that displays plasticity to alterations at the 2-OH position of donor substrates created an efficient α-mannoside-synthesizing biocatalyst. A simple fluoride donor reagent was used for the synthesis of a range of mono-α-mannosylated conjugates using the α-mannosynthase displaying low (unwanted) oligomerization activity. Copyright © 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.
Publication status:
Published

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Publisher copy:
10.1002/anie.201201081

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Angewandte Chemie (International ed. in English)
Volume:
51
Issue:
30
Pages:
7449-7453
Publication date:
2012-07-01
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Source identifiers:
339834
Language:
English
Keywords:
Pubs id:
pubs:339834
UUID:
uuid:459a8a18-01a3-4adb-bf45-d1ba1934bc49
Local pid:
pubs:339834
Deposit date:
2012-12-19

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