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Creation of an α-mannosynthase from a broad glycosidase scaffold.

Abstract:
α-Mannosides made easy: Mutation of a family-GH31 α-glucosidase that displays plasticity to alterations at the 2-OH position of donor substrates created an efficient α-mannoside-synthesizing biocatalyst. A simple fluoride donor reagent was used for the synthesis of a range of mono-α-mannosylated conjugates using the α-mannosynthase displaying low (unwanted) oligomerization activity. Copyright © 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.
Publication status:
Published

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Publisher copy:
10.1002/anie.201201081

Authors


Yamamoto, K More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
Angewandte Chemie (International ed. in English)
Volume:
51
Issue:
30
Pages:
7449-7453
Publication date:
2012-07-05
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
URN:
uuid:459a8a18-01a3-4adb-bf45-d1ba1934bc49
Source identifiers:
339834
Local pid:
pubs:339834

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