- α-Mannosides made easy: Mutation of a family-GH31 α-glucosidase that displays plasticity to alterations at the 2-OH position of donor substrates created an efficient α-mannoside-synthesizing biocatalyst. A simple fluoride donor reagent was used for the synthesis of a range of mono-α-mannosylated conjugates using the α-mannosynthase displaying low (unwanted) oligomerization activity. Copyright © 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.
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Creation of an α-mannosynthase from a broad glycosidase scaffold.
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