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Upregulation of AMPA receptor GluR2 (GluA2) subunits in subcortical ischemic vascular dementia is repressed in the presence of Alzheimer's disease.

Abstract:

Glutamatergic AMPA receptors are of clinical significance in dementia because of their roles in mediating fast excitatory neurotransmission and other synaptic events relevant to cognition. Reductions in the AMPA receptor GluR2 subunit are well-established in Alzheimer's disease (AD), but the status of GluR2 in subcortical ischemic vascular dementia (SIVD) and mixed AD/SIVD (MIX) has not been investigated. In this study we measured GluR2 immunoreactivity and mRNA levels in the postmortem neoco...

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Publication status:
Published

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Authors


Mohamed, NE More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
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Journal:
Neurochemistry international
Volume:
58
Issue:
7
Pages:
820-825
Publication date:
2011-06-05
DOI:
EISSN:
1872-9754
ISSN:
0197-0186
URN:
uuid:45922435-1597-40ab-9678-3c3f18e484bc
Source identifiers:
135204
Local pid:
pubs:135204

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