Journal article icon

Journal article

Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.

Abstract:

Malonyl-coenzyme A decarboxylase (MCD) is found from bacteria to humans, has important roles in regulating fatty acid metabolism and food intake, and is an attractive target for drug discovery. We report here four crystal structures of MCD from human, Rhodopseudomonas palustris, Agrobacterium vitis, and Cupriavidus metallidurans at up to 2.3 Å resolution. The MCD monomer contains an N-terminal helical domain involved in oligomerization and a C-terminal catalytic domain. The four structures ex...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.str.2013.05.001

Authors


Froese, DS More by this author
Forouhar, F More by this author
Vollmar, M More by this author
Expand authors...
Journal:
Structure (London, England : 1993)
Volume:
21
Issue:
7
Pages:
1182-1192
Publication date:
2013-07-05
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
URN:
uuid:4582da13-4cec-4d8f-b7cd-d9a3829ca8e6
Source identifiers:
407601
Local pid:
pubs:407601

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP