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Journal article

Activated T lymphocytes support osteoclast formation in vitro.

Abstract:

Osteoblastic stromal cells are capable of supporting osteoclast formation from hematopoietic precursors in the presence of osteotropic factors such as 1alpha,25(OH)(2)D(3), PTH, and IL-11. Osteoblastic stromal cells produce receptor activator of NF-kappaB ligand (RANKL), a type II membrane protein of the TNF ligand family, in response to these agents. Activated T lymphocytes also produce RANKL; however, the ability of this cell type to support osteoclast formation in vitro is unknown. Human P...

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Publisher copy:
10.1006/bbrc.1999.1623

Authors


Horwood, NJ More by this author
Kartsogiannis, V More by this author
Martin, TJ More by this author
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Journal:
Biochemical and biophysical research communications
Volume:
265
Issue:
1
Pages:
144-150
Publication date:
1999-11-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:4571f58a-be46-4635-ae6c-196c992a4ca5
Source identifiers:
429434
Local pid:
pubs:429434

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