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Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines.

Abstract:

OBJECTIVE: Aberrant synaptic connectivity may underlie the involvement of the hippocampus in schizophrenia. There is reasonable neuropathological evidence for a presynaptic pathology but few studies of the postsynaptic component. This study tested the hypothesis that hippocampal dendritic pathology is also present in schizophrenia. METHOD: Using in situ hybridization in sections of hippocampal formation from 10 patients with schizophrenia, 10 patients with mood disorders (three with bipolar ...

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Publication status:
Published

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Authors


Weickert, CS More by this author
Kleinman, JE More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Journal:
The American journal of psychiatry
Volume:
161
Issue:
10
Pages:
1848-1855
Publication date:
2004-10-05
DOI:
EISSN:
1535-7228
ISSN:
0002-953X
URN:
uuid:4571da0f-ac95-490c-a7a2-0cbd45bba4d4
Source identifiers:
97935
Local pid:
pubs:97935

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