- Abstract:
-
Acute kidney injury independently predicts mortality in falciparum malaria. It is not known whether acetaminophen's capacity to inhibit plasma hemoglobin-mediated oxidation is renoprotective in severe malaria.A phase 2, open-label, randomized controlled trial at two hospitals in Bangladesh was conducted to assess effects on renal function, safety, pharmacokinetic properties and pharmacodynamic effects of acetaminophen. Febrile patients ( >12 years) with severe and moderately severe falcipa...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 483.1KB)
-
- Publisher copy:
- 10.1093/cid/ciy213
-
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- Grant:
- 605807, and Fellowships to NMA and TWY
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Clinical Infectious Diseases Journal website
- Volume:
- 67
- Issue:
- 7
- Pages:
- 991–999
- Publication date:
- 2018-03-12
- Acceptance date:
- 2018-03-05
- DOI:
- EISSN:
-
1537-6591
- ISSN:
-
1058-4838
- Pubs id:
-
pubs:830372
- URN:
-
uri:45647da0-731b-42c8-b699-2e2078183303
- UUID:
-
uuid:45647da0-731b-42c8-b699-2e2078183303
- Local pid:
- pubs:830372
- Language:
- English
- Keywords:
- Copyright holder:
- Plewes et al.
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 The Authors. Published by Oxford University Press for the Infectious Diseases Society of America.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Journal article
Acetaminophen as a renoprotective adjunctive treatment in patients with severe and moderately severe Falciparum malaria: a randomized, controlled, open-label trial
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+ Australian National Health and Medical Research Council
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