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Acetaminophen as a renoprotective adjunctive treatment in patients with severe and moderately severe Falciparum malaria: a randomized, controlled, open-label trial

Abstract:

Acute kidney injury independently predicts mortality in falciparum malaria. It is not known whether acetaminophen's capacity to inhibit plasma hemoglobin-mediated oxidation is renoprotective in severe malaria.A phase 2, open-label, randomized controlled trial at two hospitals in Bangladesh was conducted to assess effects on renal function, safety, pharmacokinetic properties and pharmacodynamic effects of acetaminophen. Febrile patients ( >12 years) with severe and moderately severe falcipa...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/cid/ciy213

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Oxford college:
Green Templeton College
Role:
Author
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Publisher:
Oxford University Press Publisher's website
Journal:
Clinical Infectious Diseases Journal website
Volume:
67
Issue:
7
Pages:
991–999
Publication date:
2018-03-12
Acceptance date:
2018-03-05
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
Pubs id:
pubs:830372
URN:
uri:45647da0-731b-42c8-b699-2e2078183303
UUID:
uuid:45647da0-731b-42c8-b699-2e2078183303
Local pid:
pubs:830372

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