Journal article
Acetaminophen as a renoprotective adjunctive treatment in patients with severe and moderately severe Falciparum malaria: a randomized, controlled, open-label trial
- Abstract:
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Acute kidney injury independently predicts mortality in falciparum malaria. It is not known whether acetaminophen's capacity to inhibit plasma hemoglobin-mediated oxidation is renoprotective in severe malaria.A phase 2, open-label, randomized controlled trial at two hospitals in Bangladesh was conducted to assess effects on renal function, safety, pharmacokinetic properties and pharmacodynamic effects of acetaminophen. Febrile patients ( >12 years) with severe and moderately severe falcipa...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 483.1KB)
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- Publisher copy:
- 10.1093/cid/ciy213
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Authors
Funding
+ Infectious Diseases Society of America
More from this funder
Funding agency for:
Plewes, K
Grant:
Clinician Investigator Program
+ University of British Columbia, Canada
More from this funder
Funding agency for:
Plewes, K
Grant:
Clinician Investigator Program
+ Australian National Health and Medical Research Council
More from this funder
Grant:
FellowshipstoNMA
605807,
TWY
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Clinical Infectious Diseases Journal website
- Volume:
- 67
- Issue:
- 7
- Pages:
- 991–999
- Publication date:
- 2018-03-12
- Acceptance date:
- 2018-03-05
- DOI:
- EISSN:
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1537-6591
- ISSN:
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1058-4838
- Pmid:
-
29538635
- Source identifiers:
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830372
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:830372
- UUID:
-
uuid:45647da0-731b-42c8-b699-2e2078183303
- Local pid:
- pubs:830372
- Deposit date:
- 2018-03-20
Terms of use
- Copyright holder:
- Plewes et al
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 The Authors. Published by Oxford University Press for the Infectious Diseases Society of America.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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