Acetaminophen as a renoprotective adjunctive treatment in patients with severe and moderately severe Falciparum malaria: a randomized, controlled, open-label trial
Acute kidney injury independently predicts mortality in falciparum malaria. It is not known whether acetaminophen's capacity to inhibit plasma hemoglobin-mediated oxidation is renoprotective in severe malaria.A phase 2, open-label, randomized controlled trial at two hospitals in Bangladesh was conducted to assess effects on renal function, safety, pharmacokinetic properties and pharmacodynamic effects of acetaminophen. Febrile patients ( >12 years) with severe and moderately severe falcipa...Expand abstract
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- Plewes et al
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