Acetaminophen as a renoprotective adjunctive treatment in patients with severe and moderately severe Falciparum malaria: a randomized, controlled, open-label trial

Plewes, K; Kingston, HWF; Ghose, A; Wattanakul, T; Hassan, MMU; Haider, MS; Dutta, PK; Islam, MA; Alam, S; Jahangir, SM; Zahed, ASM; Sattar, MA; Chowdhury, MAH; Herdman, MT; Leopold, SJ; Ishioka, H; Piera, KA; Charunwatthana, P; Silamut, K; Yeo, TW; Lee, SJ; Mukaka, M; Maude, RJ; Turner, GDH; Faiz, MA; Tarning, J; Oates, JA; Anstey, NM; White, NJ; Day, NPJ; Hossain, MA; Roberts, LJ; Dondorp, AM

Journal article

Acetaminophen as a renoprotective adjunctive treatment in patients with severe and moderately severe Falciparum malaria: a randomized, controlled, open-label trial

Abstract:: Acute kidney injury independently predicts mortality in falciparum malaria. It is not known whether acetaminophen's capacity to inhibit plasma hemoglobin-mediated oxidation is renoprotective in severe malaria.A phase 2, open-label, randomized controlled trial at two hospitals in Bangladesh was conducted to assess effects on renal function, safety, pharmacokinetic properties and pharmacodynamic effects of acetaminophen. Febrile patients ( >12 years) with severe and moderately severe falcipa...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Plewes, K., Kingston, H. W. F., Ghose, A., Wattanakul, T., Hassan, M. M. U., Haider, M. S., Dutta, P. K., Islam, M. A., Alam, S., Jahangir, S. M., Zahed, A. S. M., Sattar, M. A., Chowdhury, M. A. H., Herdman, M. T., Leopold, S. J., Ishioka, H., Piera, K. A., Charunwatthana, P., Silamut, K., … Dondorp, A. M. (2018). Acetaminophen as a renoprotective adjunctive treatment in patients with severe and moderately severe Falciparum malaria: a randomized, controlled, open-label trial. Clinical Infectious Diseases, 67(7), 991–999.

MLA Style

Plewes, K., et al. “Acetaminophen as a Renoprotective Adjunctive Treatment in Patients with Severe and Moderately Severe Falciparum Malaria: a Randomized, Controlled, Open-Label Trial.” Clinical Infectious Diseases, vol. 67, no. 7, Oxford University Press, 2018, pp. 991–99.

Chicago Style

Plewes, K, HWF Kingston, A Ghose, T Wattanakul, MMU Hassan, MS Haider, PK Dutta, et al. 2018. “Acetaminophen as a Renoprotective Adjunctive Treatment in Patients with Severe and Moderately Severe Falciparum Malaria: a Randomized, Controlled, Open-Label Trial.” Clinical Infectious Diseases 67 (7): 991–99.
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Files:: ciy213.pdf

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Publisher copy:: 10.1093/cid/ciy213

Authors

+ Plewes, K More by this author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Oxford college:

Green Templeton College

Role:

Author

+ Kingston, HWF More by this author

Role:

Author

+ Ghose, A More by this author

Role:

Author

+ Wattanakul, T More by this author

Role:

Author

+ Hassan, MMU More by this author

Role:

Author

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Funding

+ University of British Columbia, Canada More from this funder

Funding agency for:

Plewes, K

Grant:

Clinician Investigator Program

+ Infectious Diseases Society of America More from this funder

Funding agency for:

Plewes, K

Grant:

Clinician Investigator Program

+ National Institutes of Health More from this funder

Grant:

GM15431to LJR

JAO

+ Bill and Melinda Gates Foundation More from this funder

Grant:

OPP1134284 to JT

+ Australian National Health and Medical Research Council More from this funder

Grant:

FellowshipstoNMA

605807,

TWY

More funders...

Bibliographic Details

Publisher:: Oxford University Press
Journal:: Clinical Infectious Diseases More from this journal
Volume:: 67
Issue:: 7
Pages:: 991–999
Publication date:: 2018-03-12
Acceptance date:: 2018-03-05
DOI:: 10.1093/cid/ciy213
EISSN:: 1537-6591
ISSN:: 1058-4838
Pmid:: 29538635

Item Description

Language:: English
Keywords:: cell-free hemoglobin

Falciparum malaria

oxidative stress

acute kidney injury

acetaminophen
Pubs id:: pubs:830372
UUID:: uuid:45647da0-731b-42c8-b699-2e2078183303
Local pid:: pubs:830372
Source identifiers:: 830372
Deposit date:: 2018-03-20

Terms of use

Copyright holder:: Plewes et al
Notes:: Copyright © 2018 The Authors. Published by Oxford University Press for the Infectious Diseases Society of America.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

Licence:: CC Attribution (CC BY)

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Journal article

Acetaminophen as a renoprotective adjunctive treatment in patients with severe and moderately severe Falciparum malaria: a randomized, controlled, open-label trial

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