Journal article icon

Journal article

Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells.

Abstract:

Coordination of cellular processes through the establishment of tissue-specific gene expression programs is essential for lineage maturation. The basic helix-loop-helix hemopoietic transcriptional regulator TAL1 (formerly SCL) is required for terminal differentiation of red blood cells. To gain insight into TAL1 function and mechanisms of action in erythropoiesis, we performed ChIP-sequencing and gene expression analyses from primary fetal liver erythroid cells. We show that TAL1 coordinates ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1101/gr.104935.110

Authors


Kassouf, MT More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
McGowan, SJ More by this author
Expand authors...
Journal:
Genome research
Volume:
20
Issue:
8
Pages:
1064-1083
Publication date:
2010-08-05
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
URN:
uuid:455d0d83-d069-4afc-86e9-b6c2bb1d7017
Source identifiers:
60645
Local pid:
pubs:60645

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP