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Inhibition of mycobacterial growth in vitro following primary but not secondary vaccination with Mycobacterium bovis BCG.

Abstract:

Despite the widespread use of the Mycobacterium bovis BCG vaccine, there are more than 9 million new cases of tuberculosis (TB) every year, and there is an urgent need for better TB vaccines. TB vaccine candidates are selected for evaluation based in part on the detection of an antigen-specific gamma interferon (IFN-γ) response. The measurement of mycobacterial growth in blood specimens obtained from subjects immunized with investigational TB vaccines may be a better in vitro correlate of in ...

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Publication status:
Published

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Publisher copy:
10.1128/cvi.00427-13

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
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Journal:
Clinical and vaccine immunology : CVI
Volume:
20
Issue:
11
Pages:
1683-1689
Publication date:
2013-11-05
DOI:
EISSN:
1556-679X
ISSN:
1556-6811
URN:
uuid:45540f89-2e9f-4049-85b4-a946f75dd2ea
Source identifiers:
420912
Local pid:
pubs:420912

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