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Novel lipopolysaccharide biosynthetic genes containing tetranucleotide repeats in Haemophilus influenzae, identification of a gene for adding O-acetyl groups.

Abstract:

Many of the genes for lipopolysaccharide (LPS) biosynthesis in Haemophilus influenzae are phase variable. The mechanism of this variable expression involves slippage of tetranucleotide repeats located within the reading frame of these genes. Based on this, we hypothesized that tetranucleotide repeat sequences might be used to identify as yet unrecognized LPS biosynthetic genes. Synthetic oligonucleotides (20 bases), representing all previously reported LPS-related tetranucleotide repeat seque...

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Publication status:
Published

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Authors


Yildirim, HH More by this author
Deadman, ME More by this author
Schweda, EK More by this author
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Journal:
Molecular microbiology
Volume:
58
Issue:
1
Pages:
207-216
Publication date:
2005-10-05
DOI:
EISSN:
1365-2958
ISSN:
0950-382X
URN:
uuid:454d7850-5888-4cc4-a8c6-b1b13492400b
Source identifiers:
115601
Local pid:
pubs:115601

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