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Investigation into the health effects of reduced chymase function using predicted loss-of-function mutations in CMA1

Abstract:

Tissue remodelling and fibrosis which occur in response to injury play a central role in the development of many diseases. Chymase is a key enzyme believed to mediate these pathological processes. As such, chymase inhibitors have been under active development for the treatment of a number of conditions. To investigate the impact of reduced chymase function, we constructed a genetic score from two pLoF mutations in the gene encoding chymase and tested its association with diseases and biomarke...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s12265-022-10261-w

Authors


Publisher:
Springer
Journal:
Journal of Cardiovascular Translational Research More from this journal
Volume:
15
Pages:
1474-1476
Place of publication:
United States
Publication date:
2022-05-05
Acceptance date:
2022-04-13
DOI:
EISSN:
1937-5395
ISSN:
1937-5387
Pmid:
35513594
Language:
English
Keywords:
Pubs id:
1257185
Local pid:
pubs:1257185
Deposit date:
2022-05-23

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