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Nigrostriatal damage is required for induction of dyskinesias by L-DOPA in squirrel monkeys.

Abstract:

We examined the ability of L-DOPA to induce dyskinesias in MPTP-treated and normal squirrel monkeys to establish whether the underlying neuropathology associated with parkinsonism is an absolute requirement or merely promotes the development of drug-induced dyskinesias. Administration of L-DOPA (5-40 mg/kg p.o., following a 60 min pretreatment with carbidopa 2.5-20 mg/kg p.o.) induced a range of dopamine-mediated behaviours including locomotor activity, stereotyped scratching, and climbing in...

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Publication status:
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Authors


Rupniak, NM More by this author
Steventon, MJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Journal:
Clinical neuropharmacology
Volume:
13
Issue:
5
Pages:
448-458
Publication date:
1990-10-05
DOI:
EISSN:
1537-162X
ISSN:
0362-5664
URN:
uuid:45418306-773f-442b-b4b9-e5ecdd374c13
Source identifiers:
27557
Local pid:
pubs:27557

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