We examined the ability of L-DOPA to induce dyskinesias in MPTP-treated and normal squirrel monkeys to establish whether the underlying neuropathology associated with parkinsonism is an absolute requirement or merely promotes the development of drug-induced dyskinesias. Administration of L-DOPA (5-40 mg/kg p.o., following a 60 min pretreatment with carbidopa 2.5-20 mg/kg p.o.) induced a range of dopamine-mediated behaviours including locomotor activity, stereotyped scratching, and climbing in...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Nigrostriatal damage is required for induction of dyskinesias by L-DOPA in squirrel monkeys.
If you are the owner of this record, you can report an update to it here: Report update to this record