- Abstract:
-
We examined the ability of L-DOPA to induce dyskinesias in MPTP-treated and normal squirrel monkeys to establish whether the underlying neuropathology associated with parkinsonism is an absolute requirement or merely promotes the development of drug-induced dyskinesias. Administration of L-DOPA (5-40 mg/kg p.o., following a 60 min pretreatment with carbidopa 2.5-20 mg/kg p.o.) induced a range of dopamine-mediated behaviours including locomotor activity, stereotyped scratching, and climbing in...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1097/00002826-199010000-00006
-
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- Journal:
- Clinical neuropharmacology
- Volume:
- 13
- Issue:
- 5
- Pages:
- 448-458
- Publication date:
- 1990-10-05
- DOI:
- EISSN:
-
1537-162X
- ISSN:
-
0362-5664
- URN:
-
uuid:45418306-773f-442b-b4b9-e5ecdd374c13
- Source identifiers:
-
27557
- Local pid:
- pubs:27557
- Language:
- English
- Keywords:
- Copyright date:
- 1990
Journal article
Nigrostriatal damage is required for induction of dyskinesias by L-DOPA in squirrel monkeys.
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