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Advances in the synthesis of nitroxide radicals for use in biomolecule spin labelling

Abstract:

EPR spectroscopy is an increasingly useful analytical tool to probe biomolecule structure, dynamic behaviour, and interactions. Nitroxide radicals are the most commonly used radical probe in EPR experiments, and many methods have been developed for their synthesis, as well as incorporation into biomolecules using site-directed spin labelling. In this Tutorial Review, we discuss the most practical methods for the synthesis of nitroxides, focusing on the tunability of their structures, the mani...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1039/c6cs00550k

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More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Role:
Author
ORCID:
0000-0001-7017-344X
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Oxford college:
Jesus College
Role:
Author
ORCID:
0000-0002-4149-0494
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Chemical Society Reviews Journal website
Volume:
47
Issue:
3
Pages:
668-680
Publication date:
2017-12-01
Acceptance date:
2017-11-20
DOI:
EISSN:
1460-4744
ISSN:
0306-0012
Pubs id:
pubs:811182
URN:
uri:453bbbd1-3e61-4204-be84-b5fad1769144
UUID:
uuid:453bbbd1-3e61-4204-be84-b5fad1769144
Local pid:
pubs:811182
Paper number:
3
Language:
English

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