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Catechol-o-methyltransferase enzyme activity and protein expression in human prefrontal cortex across the postnatal lifespan.

Abstract:

The prefrontal cortex (PFC) dopamine system, which is critical for modulating PFC function, undergoes remodeling until at least young adulthood in primates. Catechol-o-methyltransferase (COMT) alters extracellular dopamine levels in PFC, and its gene contains a functional polymorphism (Val(158)Met) that has been associated with variation in PFC function. We examined COMT enzyme activity and protein immunoreactivity in the PFC during human postnatal development. Protein was extracted from PFC ...

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Publication status:
Published

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Publisher copy:
10.1093/cercor/bhl032

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
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Journal:
Cerebral cortex (New York, N.Y. : 1991)
Volume:
17
Issue:
5
Pages:
1206-1212
Publication date:
2007-05-05
DOI:
EISSN:
1460-2199
ISSN:
1047-3211
URN:
uuid:451ef7f2-5a12-42ac-86e5-54438d031627
Source identifiers:
97951
Local pid:
pubs:97951

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