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Modulation of dendritic cell endocytosis and antigen processing pathways by Escherichia coli heat-labile enterotoxin and mutant derivatives.

Abstract:

Escherichia coli heat-labile enterotoxin (LT) is known to be a potent adjuvant of both the mucosal and systemic immune systems but the mechanism of action leading to adjuvant activity remains incompletely understood. This study investigates the action of LT and LT mutants with impaired enzymatic activity, on the function of dendritic cells. Wild-type LT and LTR72, which retains some ADP ribosyltransferase activity, induced a selective increase in cell surface expression of B7.1, and a selecti...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Role:
Author
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Journal:
Vaccine
Volume:
21
Issue:
13-14
Pages:
1445-1454
Publication date:
2003-03-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:451ec776-3653-4bb0-aa23-2edfedfc1a33
Source identifiers:
98266
Local pid:
pubs:98266

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