Journal article
The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver.
- Abstract:
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Genome-wide association studies have identified a number of signals for both Type 2 Diabetes and related quantitative traits. For the majority of loci, the transition from association signal to mutational mechanism has been difficult to establish. Glucokinase (GCK) regulates glucose storage and disposal in the liver where its activity is regulated by glucokinase regulatory protein (GKRP; gene name GCKR). Fructose-6 and fructose-1 phosphate (F6P and F1P) enhance or reduce GKRP-mediated inhibit...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 203.9KB, Terms of use)
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- Publisher copy:
- 10.1093/hmg/ddp357
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Funding
Bibliographic Details
- Publisher:
- Oxford University Press
- Journal:
- Human molecular genetics More from this journal
- Volume:
- 18
- Issue:
- 21
- Pages:
- 4081-4088
- Publication date:
- 2009-11-01
- DOI:
- EISSN:
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1460-2083
- ISSN:
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0964-6906
Item Description
- Language:
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English
- Keywords:
- UUID:
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uuid:451bc29f-1e1f-4c55-940a-e76b11b84d15
- Local pid:
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pubs:9550
- Source identifiers:
-
9550
- Deposit date:
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2012-12-19
Terms of use
- Copyright holder:
- Beer et al
- Copyright date:
- 2009
- Notes:
- Copyright © 2009 Beer et al. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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