Journal article icon

Journal article

Somatic hypermutations confer rheumatoid factor activity in hepatitis C virus-associated mixed cryoglobulinemia.

Abstract:

OBJECTIVE: Hepatitis C virus (HCV) is the most frequent cause of mixed cryoglobulinemia (MC), which is characterized by endothelial deposition of rheumatoid factor (RF)-containing immune complexes and end-organ vasculitis. MC is a lymphoproliferative disorder in which B cells express RF-like Ig, yet its precise antigenic stimulus is unknown. We have proposed that IgG-HCV immune complexes stimulate B cell expansion and somatic hypermutation (SHM)-induced affinity maturation in part via engagem...

Expand abstract

Actions


Access Document


Publisher copy:
10.1002/art.38041

Authors


Charles, ED More by this author
Orloff, MI More by this author
Nishiuchi, E More by this author
Marukian, S More by this author
Expand authors...
Journal:
Arthritis and rheumatism
Volume:
65
Issue:
9
Pages:
2430-2440
Publication date:
2013-09-29
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:450d1c09-3854-41c7-be1e-49f49b6b2bc9
Source identifiers:
426213
Local pid:
pubs:426213

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP