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Embryos generated from oocytes lacking complex N- and O-glycans have compromised development and implantation.

Abstract:

Female mice generating oocytes lacking complex N- and O-glycans (double mutants (DM)) produce only one small litter before undergoing premature ovarian failure (POF) by 3 months. Here we investigate the basis of the small litter by evaluating ovulation rate and embryo development in DM (Mgat1(F/F)C1galt1(F/F):ZP3Cre) and Control (Mgat1(F/F)C1galt1(F/F)) females. Surprisingly, DM ovulation rate was normal at 6 weeks, but declined dramatically by 9 weeks. In vitro development of zygotes to blas...

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Publication status:
Published

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Publisher copy:
10.1530/rep-12-0084

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Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
Journal:
Reproduction (Cambridge, England)
Volume:
144
Issue:
4
Pages:
455-465
Publication date:
2012-10-01
DOI:
EISSN:
1741-7899
ISSN:
1470-1626
Source identifiers:
349833

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