Journal article
A versatile transgenic allele for mouse overexpression studies
- Abstract:
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For the analysis of gene function in vivo, gene overexpression in the mouse provides an alternative to loss-of-function knock-out approaches and can help reveal phenotypes where compensatory mechanisms are at play. Furthermore, when multiple lines overexpressing a gene-of-interest at varying levels are studied, the consequences of differences in gene dosage can be explored. Despite these advantages, inherent shortcomings in the methodologies used for the generation of gain-of-function transge...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 3.6MB, Terms of use)
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(Preview, Version of record, pdf, 1.9MB, Terms of use)
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- Publisher copy:
- 10.1007/s00335-015-9602-y
Authors
Funding
+ British Heart Foundation Centre for Research Excellence
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Grant:
RE/08/004/23915
Bibliographic Details
- Publisher:
- Springer US
- Journal:
- Mammalian Genome More from this journal
- Volume:
- 26
- Issue:
- 11-12
- Pages:
- 598-608
- Publication date:
- 2015-09-14
- DOI:
- EISSN:
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1432-1777
- ISSN:
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0938-8990
Item Description
- Keywords:
- Pubs id:
-
pubs:579437
- UUID:
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uuid:45099d1b-5066-43cb-9212-c55c56d312ef
- Local pid:
-
pubs:579437
- Source identifiers:
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579437
- Deposit date:
-
2016-02-04
Terms of use
- Copyright holder:
- Dolatshad et al
- Copyright date:
- 2015
- Notes:
- © The Authors 2015. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Licence:
- CC Attribution (CC BY)
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