Journal article
Botulism and tetanus
- Abstract:
- Botulism and tetanus are diseases caused by neurotoxins produced by Clostridium botulinum and Clostridium tetani, respectively. The bacteria and the toxins they produce are closely related. Both diseases are rare in the UK and the developed world, but tetanus, in particular, is a major cause of death in the developing world, causing between 100,000 and 200,000 deaths each year. In botulism a descending flaccid paralysis occurs, whereas in tetanus generalized muscle spasms develop. Autonomic nervous system dysfunction can occur in either disease, and in tetanus cardiovascular parameters can fluctuate widely. Early involvement of respiratory muscles means that rapid recognition and prompt institution of supportive measures are important in improving survival.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 308.6KB, Terms of use)
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- Publisher copy:
- 10.1016/j.mpmed.2017.09.004
Authors
- Publisher:
- Elsevier
- Journal:
- Medicine More from this journal
- Volume:
- 45
- Issue:
- 12
- Pages:
- 739-742
- Publication date:
- 2017-10-27
- Acceptance date:
- 2017-09-15
- DOI:
- EISSN:
-
1365-4357
- ISSN:
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1357-3039
- Keywords:
- Pubs id:
-
pubs:746082
- UUID:
-
uuid:4507aeb0-b787-48a0-8ad9-4e00d7875a8b
- Local pid:
-
pubs:746082
- Source identifiers:
-
746082
- Deposit date:
-
2017-11-20
Terms of use
- Copyright holder:
- Elsevier Ltd
- Copyright date:
- 2017
- Notes:
- © 2017 Published by Elsevier Ltd. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.mpmed.2017.09.004
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