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'There and back again': revisiting the pathophysiological roles of human endogenous retroviruses in the post-genomic era.

Abstract:

Almost 8% of the human genome comprises endogenous retroviruses (ERVs). While they have been shown to cause specific pathologies in animals, such as cancer, their association with disease in humans remains controversial. The limited evidence is partly due to the physical and bioethical restrictions surrounding the study of transposons in humans, coupled with the major experimental and bioinformatics challenges surrounding the association of ERVs with disease in general. Two biotechnological l...

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Publication status:
Published online

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Publisher copy:
10.1098/rstb.2012.0504

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
Journal:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume:
368
Issue:
1626
Pages:
20120504
Chapter number:
ARTN 20120504
Publication date:
2013-09-05
DOI:
EISSN:
1471-2970
ISSN:
0962-8436
URN:
uuid:44eef38d-36b5-4008-b2a2-0a8f78a94755
Source identifiers:
418317
Local pid:
pubs:418317

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