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Thesis

Structural characterisation of the interaction between Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) and their human ligands in severe malaria

Abstract:

Sequestration of infected erythrocytes during P. falciparum infection can lead to severe malaria. PfEMP1 proteins are central to this process. Multimodular PfEMP1 proteins can bind to a variety of human ligands due to the presence of CIDR and DBL domains. CIDR and DBL domains are classified to three and six families respectively, with each thought to bind to unique human ligands. The interaction between PfEMP1 proteins and human ligands protects the infected erythrocytes against spleen-med...

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Institution:
University of Oxford
Oxford college:
Merton College

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Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral

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