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A functional analysis of a natural variant of intercellular adhesion molecule-1 (ICAM-1Kilifi).

Abstract:

Intercellular adhesion molecule-1 (ICAM-1) is involved in a range of interactions both within the host and between the host and a number of pathogens. Recently we described a mutation within the coding region of the first N-terminal immunoglobulin-like domain of ICAM-1, present at high frequency within African populations, which increased the risk of cerebral malaria. To understand the mechanism by which such a polymorphism might be maintained despite counter-selection by malaria, we have car...

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Publisher copy:
10.1093/hmg/9.4.525

Authors


Fernandez-Reyes, D More by this author
McDowall, A More by this author
Altieri, DC More by this author
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Journal:
Human molecular genetics
Volume:
9
Issue:
4
Pages:
525-530
Publication date:
2000-03-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:44bef8c7-1c8f-41b3-8637-4129a91b9906
Source identifiers:
94854
Local pid:
pubs:94854

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