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Genome-wide analysis of the zebrafish ETS family identifies three genes required for hemangioblast differentiation or angiogenesis.

Abstract:

ETS domain transcription factors have been linked to hematopoiesis, vasculogenesis, and angiogenesis. However, their biological functions and the mechanisms of action, remain incompletely understood. Here, we have performed a systematic analysis of zebrafish ETS domain genes and identified 31 in the genome. Detailed gene expression profiling revealed that 12 of them are expressed in blood and endothelial precursors during embryonic development. Combined with a phylogenetic tree assay, this su...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, BHF Centre of Research Excellence
Role:
Author
Journal:
Circulation research
Volume:
103
Issue:
10
Pages:
1147-1154
Publication date:
2008-11-05
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
URN:
uuid:44bbf8ca-21e4-44b2-becb-610235af4ba7
Source identifiers:
106541
Local pid:
pubs:106541

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