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Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence.

Abstract:

Persistent hepatitis B virus infection is a major risk factor for hepatocellular carcinoma, the most frequent cancer in some developing countries. Up to 95% of those infected at birth and 15% of those infected after the neonatal period fail to clear hepatitis B virus, together resulting in approximately 350 million persistent carriers worldwide. Via a whole genome scan in Gambian families, we have identified a major susceptibility locus as a cluster of class II cytokine receptor genes on chro...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0602800103

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
103
Issue:
24
Pages:
9148-9153
Publication date:
2006-06-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
33497

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