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Journal article

Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases.

Abstract:
There's always a catch. The post-translational modification of proteins with ubiquitin (Ub) or ubiquitin-like (Ubl) modifiers is an important signal in the regulation of a variety of biological processes, such as degradation and regulation of gene expression. Here we report the synthesis of a panel of peptide vinyl sulfones (see scheme) harboring various portions of the Ub C terminus by using a safety-catch linker. Depending on their length, such compounds can efficiently target Ubl-specific proteases. © 2005 Wiley-VCH Verlag GmbH and Co. KGaA.
Publication status:
Published

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Publisher copy:
10.1002/cbic.200400236

Authors


Borodovsky, A More by this author
Meester, WJ More by this author
Venanzi, ES More by this author
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Journal:
Chembiochem : a European journal of chemical biology
Volume:
6
Issue:
2
Pages:
287-291
Publication date:
2005-02-05
DOI:
EISSN:
1439-7633
ISSN:
1439-4227
URN:
uuid:44a5c03e-9dcb-4d4e-8488-3f87a37d9bfc
Source identifiers:
3306
Local pid:
pubs:3306

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