- There's always a catch. The post-translational modification of proteins with ubiquitin (Ub) or ubiquitin-like (Ubl) modifiers is an important signal in the regulation of a variety of biological processes, such as degradation and regulation of gene expression. Here we report the synthesis of a panel of peptide vinyl sulfones (see scheme) harboring various portions of the Ub C terminus by using a safety-catch linker. Depending on their length, such compounds can efficiently target Ubl-specific proteases. © 2005 Wiley-VCH Verlag GmbH and Co. KGaA.
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Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases.
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