Ponsin interacts with Nck adapter proteins: implications for a role in cytoskeletal remodelling during differentiation of skeletal muscle cells.

Journal article

Skeletal muscle differentiation is a complex process: It is characterised by changes in gene expression and protein composition. Simultaneously, a dramatic remodelling of the cytoskeleton and associated cell-matrix contacts, the costameres, occurs. The expression and localisation of the protein ponsin at cell-matrix contacts marks the establishment of costameres. In this report we show that skeletal muscle cells are characterised by a novel ponsin isoform, which contains a large insertion in ...

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Authors: Gehmlich, K; Hayess, K; Legler, C; Haebel, S; Van der Ven, P

• Journal: European journal of cell biology
• Volume: 89
• Issue: 5
• Pages: 351-364
• Publication date: 2010-05-01
• DOI: 10.1016/j.ejcb.2009.10.019
• EISSN: 1618-1298
• ISSN: 0171-9335
• Language: English
• Keywords: Phosphothreonine; Adaptor Proteins, Signal Transducing; Protein Binding; Muscle, Skeletal; Mice, Inbred mdx; Muscular Dystrophy, Animal; Muscle Cells; Substrate Specificity; Mice; Oncogene Proteins; Cell Line; Models, Biological; Sequence Analysis, Protein; Amino Acid Sequence; Organ Specificity; Protein Transport; Molecular Sequence Data; Cytoskeleton; Cell Differentiation; Microfilament Proteins; Mutagenesis, Insertional; Animals; Up-Regulation; Phosphorylation; Phosphoserine; Mitogen-Activated Protein Kinases; Humans; Proline