Journal article icon

Journal article

Integrating genealogical and dynamical modelling to infer escape and reversion rates in HIV epitopes.

Abstract:

The rates of escape and reversion in response to selection pressure arising from the host immune system, notably the cytotoxic T-lymphocyte (CTL) response, are key factors determining the evolution of HIV. Existing methods for estimating these parameters from cross-sectional population data using ordinary differential equations (ODEs) ignore information about the genealogy of sampled HIV sequences, which has the potential to cause systematic bias and overestimate certainty. Here, we describe ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1098/rspb.2013.0696

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
Journal:
Proceedings. Biological sciences / The Royal Society
Volume:
280
Issue:
1762
Pages:
20130696
Publication date:
2013-07-05
DOI:
EISSN:
1471-2954
ISSN:
0962-8452
URN:
uuid:449702ef-a75b-4922-a3dd-441ea584b0cc
Source identifiers:
401155
Local pid:
pubs:401155

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP