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Pathological grading of regression following neoadjuvant chemoradiation therapy: the clinical need is now.

Abstract:

Neoadjuvant chemoradiotherapy for locally advanced rectal cancer has been shown to decrease rates of local recurrence and more than double the rate of sphincter-preserving surgery. There is now compelling evidence that pathological complete response is an independent predictor of likelihood of local recurrence, distal metastases, disease-free and overall survival in locally advanced rectal cancer following neoadjuvant chemoradiotherapy. Pathological regression grading can therefore guide clin...

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Authors


MacGregor, TP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
Journal of clinical pathology
Volume:
65
Issue:
10
Pages:
867-871
Publication date:
2012-10-05
DOI:
EISSN:
1472-4146
ISSN:
0021-9746
URN:
uuid:448c4a16-1196-4814-ba78-20217665f520
Source identifiers:
341145
Local pid:
pubs:341145

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