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The pVHL-hIF-1 system. A key mediator of oxygen homeostasis.

Abstract:

Matching oxygen consumption and supply represents a fundamental challenge to multicellular organisms. HIF-1 is a transcription complex which is emerging as a key mediator of oxygen homeostasis. HIF-1 controls the expression of many genes, including erythropoietin, angiogenic growth factors, glucose transporters and glycolytic enzymes. The HIF-1 complex, which contains an alpha and beta subunit (both basic helix-loop-helix proteins of the PAS family) is formed in hypoxia and modulates gene exp...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
Journal:
Advances in experimental medicine and biology
Volume:
502
Pages:
365-376
Publication date:
2001-01-01
Event title:
12th International Hypoxia Symposium
ISSN:
0065-2598
Source identifiers:
19823
ISBN:
0306466961

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