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In vivo functions mediated by the p41 isoform of the MHC class II-associated invariant chain.

Abstract:

We used a "hit and run" gene targeting strategy to generate mice expressing only the p41 isoform of the conserved invariant (Ii) chain associated with MHC class II molecules. In contrast to mutants expressing only p31 Ii chain, a small proportion of A(alpha)b A(beta)b molecules produced by these animals have reduced mobilities in SDS-PAGE and appear incompletely processed. Nonetheless, class II surface expression, peptide occupancy, CD4+ T cell maturation, and proliferative responses toward i...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
158
Issue:
1
Pages:
187-199
Publication date:
1997-01-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:447f8a52-2263-40e0-b893-5ab98ddef23f
Source identifiers:
9001
Local pid:
pubs:9001

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