Journal article icon

Journal article

In vivo functions mediated by the p41 isoform of the MHC class II-associated invariant chain.

Abstract:

We used a "hit and run" gene targeting strategy to generate mice expressing only the p41 isoform of the conserved invariant (Ii) chain associated with MHC class II molecules. In contrast to mutants expressing only p31 Ii chain, a small proportion of A(alpha)b A(beta)b molecules produced by these animals have reduced mobilities in SDS-PAGE and appear incompletely processed. Nonetheless, class II surface expression, peptide occupancy, CD4+ T cell maturation, and proliferative responses toward i...

Expand abstract
Publication status:
Published

Actions


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Journal of Immunology
Volume:
158
Issue:
1
Pages:
187-199
Publication date:
1997-01-01
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
9001
Language:
English
Keywords:
Pubs id:
pubs:9001
UUID:
uuid:447f8a52-2263-40e0-b893-5ab98ddef23f
Local pid:
pubs:9001
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP