In vivo functions mediated by the p41 isoform of the MHC class II-associated invariant chain.

Takaesu, NT; Lower, JA; Yelon, D; Robertson, EJ; Bikoff, EK

Abstract:

We used a "hit and run" gene targeting strategy to generate mice expressing only the p41 isoform of the conserved invariant (Ii) chain associated with MHC class II molecules. In contrast to mutants expressing only p31 Ii chain, a small proportion of A(alpha)b A(beta)b molecules produced by these animals have reduced mobilities in SDS-PAGE and appear incompletely processed. Nonetheless, class II surface expression, peptide occupancy, CD4+ T cell maturation, and proliferative responses toward i...

Expand abstract

Publication status:

Published

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Takaesu, N. T., Lower, J. A., Yelon, D., Robertson, E. J., & Bikoff, E. K. (1997). In vivo functions mediated by the p41 isoform of the MHC class II-associated invariant chain. Journal of Immunology (Baltimore, Md. : 1950), 158(1), 187–199.

MLA Style

Takaesu, N. T., et al. “In Vivo Functions Mediated by the p41 Isoform of the MHC Class II-Associated Invariant Chain.” Journal of Immunology (Baltimore, Md. : 1950), vol. 158, no. 1, 1997, pp. 187–99.

Chicago Style

Takaesu, NT, JA Lower, D Yelon, EJ Robertson, and EK Bikoff. 1997. “In Vivo Functions Mediated by the p41 Isoform of the MHC Class II-Associated Invariant Chain.” Journal of Immunology (Baltimore, Md. : 1950) 158 (1): 187–99.
Tweet
Print