Journal article
In vivo functions mediated by the p41 isoform of the MHC class II-associated invariant chain.
- Abstract:
-
We used a "hit and run" gene targeting strategy to generate mice expressing only the p41 isoform of the conserved invariant (Ii) chain associated with MHC class II molecules. In contrast to mutants expressing only p31 Ii chain, a small proportion of A(alpha)b A(beta)b molecules produced by these animals have reduced mobilities in SDS-PAGE and appear incompletely processed. Nonetheless, class II surface expression, peptide occupancy, CD4+ T cell maturation, and proliferative responses toward i...
Expand abstract
- Publication status:
- Published
Actions
Authors
Bibliographic Details
- Journal:
- Journal of Immunology
- Volume:
- 158
- Issue:
- 1
- Pages:
- 187-199
- Publication date:
- 1997-01-01
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- Source identifiers:
-
9001
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:9001
- UUID:
-
uuid:447f8a52-2263-40e0-b893-5ab98ddef23f
- Local pid:
- pubs:9001
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1997
If you are the owner of this record, you can report an update to it here: Report update to this record