11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol.

Conference item

In humans, glucocorticoids are important regulators of adipose tissue distribution and function but circulating cortisol concentrations are normal in most patients with obesity. However, intracellular glucocorticoid levels can be modified by a microsomal enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) expressed mainly in the liver and adipose tissue. Locally generated cortisol within human adipose tissue can induce preadipocyte differentiation, but the relationship between 11b...

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Authors: Bujalska, I; Walker, E; Tomlinson, J; Hewison, M; Stewart, P

• Publication status: Published
• Host title: Endocrine research
• Volume: 28
• Issue: 4
• Pages: 449-461
• Publication date: 2002-11-01
• Event location: United States
• DOI: 10.1081/erc-120016822
• EISSN: 1532-4206
• ISSN: 0743-5800
• Keywords: Humans; Cell Differentiation; Hydroxysteroid Dehydrogenases; Stem Cells; 11-beta-Hydroxysteroid Dehydrogenase Type 1; Hydrocortisone; Omentum; Adipocytes