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11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol.

Abstract:

In humans, glucocorticoids are important regulators of adipose tissue distribution and function but circulating cortisol concentrations are normal in most patients with obesity. However, intracellular glucocorticoid levels can be modified by a microsomal enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) expressed mainly in the liver and adipose tissue. Locally generated cortisol within human adipose tissue can induce preadipocyte differentiation, but the relationship between 11b...

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Publication status:
Published

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Publisher copy:
10.1081/erc-120016822

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Role:
Author
Volume:
28
Issue:
4
Pages:
449-461
Publication date:
2002-11-05
DOI:
EISSN:
1532-4206
ISSN:
0743-5800
URN:
uuid:446ae757-4692-4afc-9daf-87835536965c
Source identifiers:
482071
Local pid:
pubs:482071

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