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11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol.

Abstract:

In humans, glucocorticoids are important regulators of adipose tissue distribution and function but circulating cortisol concentrations are normal in most patients with obesity. However, intracellular glucocorticoid levels can be modified by a microsomal enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) expressed mainly in the liver and adipose tissue. Locally generated cortisol within human adipose tissue can induce preadipocyte differentiation, but the relationship between 11b...

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Publication status:
Published

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Publisher copy:
10.1081/erc-120016822

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
Volume:
28
Issue:
4
Pages:
449-461
Host title:
Endocrine research
Publication date:
2002-11-01
Event location:
United States
DOI:
EISSN:
1532-4206
ISSN:
0743-5800
Source identifiers:
482071
Keywords:
Pubs id:
pubs:482071
UUID:
uuid:446ae757-4692-4afc-9daf-87835536965c
Local pid:
pubs:482071
Deposit date:
2014-08-29

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