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HIV drug resistance mutations in non-B subtypes after prolonged virological failure on NNRTI-based first-line regimens in sub-Saharan Africa

Abstract:

Objective: To determine drug resistance mutation (DRM) patterns in a large cohort of patients failing non-nucleoside-reverse-transcriptase-inhibitor (NNRTI)-based first-line antiretroviral therapy (ART) regimens in programmes without routine viral load (VL) monitoring and to examine inter-subtype differences in DRMs.

Design: Sequences from 787 adults/adolescents who failed an NNRTI-based first-line regimen in 13 clinics in Uganda, Kenya, Zimbabwe, Malawi were analysed. Multivariabl...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1097/QAI.0000000000001285

Authors


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Swedish International Development Cooperation Agency More from this funder
The World Health Organisation More from this funder
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Publisher:
Lippincott, Williams & Wilkins Publisher's website
Journal:
JAIDS: Journal of Acquired Immune Deficiency Syndromes Journal website
Volume:
75
Issue:
2
Pages:
e45-e54
Publication date:
2017-01-25
Acceptance date:
2016-12-08
DOI:
EISSN:
1944-7884
ISSN:
1525-4135
Source identifiers:
664909
Pubs id:
pubs:664909
UUID:
uuid:446236b1-c225-43af-bfd7-7fb818a015aa
Local pid:
pubs:664909
Deposit date:
2016-12-11

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