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Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti-tumour activity.

Abstract:

Bisphosphonates are in widespread use to prevent bone resorption in a number of metabolic and tumour-induced bone diseases including multiple myeloma. Recent reports suggest that bisphosphonate treatment may be associated with an increase in patient survival, raising the possibility that these compounds may have a direct effect on the tumour cells. We have investigated whether the bisphosphonates clodronate, pamidronate and YM175 can directly affect the human myeloma cell lines U266-B1, JJN-3...

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Publication status:
Published

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Journal:
British journal of haematology
Volume:
98
Issue:
3
Pages:
665-672
Publication date:
1997-09-05
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:44610ae9-b991-4e17-9f11-b7ebf57e1dad
Source identifiers:
384077
Local pid:
pubs:384077

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