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Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti-tumour activity.

Abstract:

Bisphosphonates are in widespread use to prevent bone resorption in a number of metabolic and tumour-induced bone diseases including multiple myeloma. Recent reports suggest that bisphosphonate treatment may be associated with an increase in patient survival, raising the possibility that these compounds may have a direct effect on the tumour cells. We have investigated whether the bisphosphonates clodronate, pamidronate and YM175 can directly affect the human myeloma cell lines U266-B1, JJN-3...

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Publication status:
Published

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Authors


Shipman, CM More by this author
Rogers, MJ More by this author
Apperley, JF More by this author
Russell, RG More by this author
Croucher, PI More by this author
Journal:
British journal of haematology
Volume:
98
Issue:
3
Pages:
665-672
Publication date:
1997-09-05
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:44610ae9-b991-4e17-9f11-b7ebf57e1dad
Source identifiers:
384077
Local pid:
pubs:384077

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