- Abstract:
-
HIV-1 accumulates mutations in and around reactive epitopes to escape recognition and killing by CD8+ T cells. Measurements of HIV-1 time to escape should therefore provide information on which parameters are most important for T cell-mediated in vivo control of HIV-1. Primary HIV-1-specific T cell responses were fully mapped in 17 individuals, and the time to virus escape, which ranged from days to years, was measured for each epitope. While higher magnitude of an individual T cell response ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1172/JCI65330
-
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- Journal:
- The Journal of clinical investigation
- Volume:
- 123
- Issue:
- 1
- Pages:
- 380-393
- Publication date:
- 2013-01-05
- DOI:
- EISSN:
-
1558-8238
- ISSN:
-
0021-9738
- URN:
-
uuid:445d49b3-07f2-4a1a-ac58-4215b86e5c2b
- Source identifiers:
-
367664
- Local pid:
- pubs:367664
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
Vertical T cell immunodominance and epitope entropy determine HIV-1 escape.
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