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Journal article

Vertical T cell immunodominance and epitope entropy determine HIV-1 escape.

Abstract:

HIV-1 accumulates mutations in and around reactive epitopes to escape recognition and killing by CD8+ T cells. Measurements of HIV-1 time to escape should therefore provide information on which parameters are most important for T cell-mediated in vivo control of HIV-1. Primary HIV-1-specific T cell responses were fully mapped in 17 individuals, and the time to virus escape, which ranged from days to years, was measured for each epitope. While higher magnitude of an individual T cell response ...

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Publication status:
Published

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Publisher copy:
10.1172/JCI65330

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Journal:
The Journal of clinical investigation
Volume:
123
Issue:
1
Pages:
380-393
Publication date:
2013-01-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:445d49b3-07f2-4a1a-ac58-4215b86e5c2b
Source identifiers:
367664
Local pid:
pubs:367664

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