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Journal article

Use of B cell-bound HLA-A2 class I monomers to generate high-avidity, allo-restricted CTLs against the leukemia-associated protein Wilms tumor antigen.

Abstract:

Recent studies have detected Wilms tumor antigen (WT1)-specific cytotoxic T lymphocytes (CTLs) in patients with acute myelogenous leukemia (AML) and chronic myelogenous leukemia (CML) and demonstrated that most of these CTLs were low avidity. Although HLA-mismatched donors can mount high-avidity CTLs against HLA-A2-presented peptides of WT1, a dominant anti-alloimmune response usually obscures detection of peptide-specific CTLs. Here we explored the feasibility of using recombinant HLA-A2 mon...

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Publication status:
Published

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Publisher copy:
10.1182/blood-2003-11-3903

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Journal:
Blood
Volume:
103
Issue:
12
Pages:
4613-4615
Publication date:
2004-06-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:44591c66-bb0e-4bce-afb9-6949ed540b5c
Source identifiers:
102220
Local pid:
pubs:102220

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