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Dopamine stimulation of postnatal murine subventricular zone neurogenesis via the D3 receptor.

Abstract:

We investigated the expression and role of the dopamine receptor 3 (D3R) in postnatal mouse subventricular zone (SVZ). In situ hybridization detected selective D3R mRNA expression in the SVZ. Fluorescence activated cell sorting (FACS) of adult SVZ subtypes using hGFAP-GFP and Dcx-GFP mice showed that transit amplifying progenitor cells and niche astrocytes expressed D3R whereas stem cell-like astrocytes and neuroblasts did not. To determine D3R's role in SVZ neurogenesis, we administered U-99...

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Publication status:
Published

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Journal:
Journal of neurochemistry
Volume:
114
Issue:
3
Pages:
750-760
Publication date:
2010-08-05
DOI:
EISSN:
1471-4159
ISSN:
0022-3042
URN:
uuid:44588147-6e21-4bd8-a783-c0ffab883f33
Source identifiers:
113873
Local pid:
pubs:113873

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