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Thesis

The energetics of nucleotide binding to RAS proteins

Abstract:

Ras proteins are a special class of proteins that mediate cell growth signals. Their importance lies in the fact that they are products of a proto-oncogene. This means that under certain conditions the gene that determines its structure is altered and a mutant protein results that is involved in the transformation of normal cells to cancer cells.

The actual function by which the protein acts in the signal pathway is not known. However it is known that they act as a switch,...

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Institution:
University of Oxford
Department:
Mathematical and Physical Sciences Division
Role:
Author

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Role:
Supervisor
Publication date:
1992
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Barcode:
603840939
URN:
uuid:44524415-2f2b-4601-998c-56110f332153
Local pid:
td:603840939
Language:
English
Subjects:

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