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Effective T-cell responses select human immunodeficiency virus mutants and slow disease progression.

Abstract:

The possession of some HLA class I molecules is associated with delayed progression to AIDS. The mechanism behind this beneficial effect is unclear. We tested the idea that cytotoxic T-cell responses restricted by advantageous HLA class I molecules impose stronger selection pressures than those restricted by other HLA class I alleles. As a measure of the selection pressure imposed by HLA class I alleles, we determined the extent of HLA class I-associated epitope variation in a cohort of Europ...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.00022-07

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Oxenius, A More by this author
Günthard, HF More by this author
Hirschel, B More by this author
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Journal:
Journal of virology
Volume:
81
Issue:
12
Pages:
6742-6751
Publication date:
2007-06-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:44509e62-e91c-4cac-90a0-927bcbcc8780
Source identifiers:
20484
Local pid:
pubs:20484

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