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Genome-wide association study of type 2 diabetes in Africa

Abstract:

Aims/hypothesis: Genome-wide association studies (GWAS) for type 2 diabetes have uncovered >400 risk loci, primarily in populations of European and Asian ancestry. Here, we aimed to discover additional type 2 diabetes risk loci (including African-specific variants) and fine-map association signals by performing genetic analysis in African populations.

Methods:We conducted two type 2 diabetes genome-wide association studies in 4347 Africans from South Africa, Nigeria, Ghana and Ke...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1007/s00125-019-4880-7

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Human Genetics Wt Centre
Adeyemo, A More by this author
Carstensen, T More by this author
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Publisher:
Springer Verlag Publisher's website
Journal:
Diabetologia Journal website
Volume:
2019
Pages:
1-8
Publication date:
2019-05-02
Acceptance date:
2019-03-22
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
Pubs id:
pubs:984385
URN:
uri:44509ad2-42ec-461d-96ed-d9769274df0e
UUID:
uuid:44509ad2-42ec-461d-96ed-d9769274df0e
Local pid:
pubs:984385

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