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Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia

Abstract:

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is believed to confer protection against Plasmodium falciparum malaria, but the precise nature of the protective effecthas proved difficult to define as G6PD deficiency has multiple allelic variants with different effects in males and females, and it has heterogeneous effects on the clinical outcome of P. falciparum infection. Here we report an analysis of multiple allelic forms of G6PD deficiency in a large multi-centre case-control study o...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.7554/eLife.15085

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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Kivinen, K More by this author
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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Funding agency for:
Spencer, CCA
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Funding agency for:
Kwiatkowski, D
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Funding agency for:
Kwiatkowski, D
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Grant:
090770/Z/09/Z; MalariaGEN Project 077383/Z/05/Z; 090532/Z/09/Z; 077012/Z/05/Z
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Grant:
Bill and Melinda Gates Foundation Grand Challenges in Global Health 566
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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
6
Pages:
Article: e15085
Publication date:
2017-01-09
DOI:
ISSN:
2050-084X
Pubs id:
pubs:670810
URN:
uri:444aa04a-3384-4bf7-9c75-8a7e7ff44394
UUID:
uuid:444aa04a-3384-4bf7-9c75-8a7e7ff44394
Local pid:
pubs:670810

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