Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia

Clarke, G; Rockett, K; Kivinen, K; Hubbart, C; Jeffreys, A; Rowlands, K; Jallow, M; Conway, D; Bojang, K; Pinder, M; Usen, S; Sisay-Joof, F; Sirugo, G; Toure, O; Thera, M; Konate, S; Sissoko, S; Niangaly, A; Poudiougou, B; Mangano, V; Bougouma, E; Sirima, S; Modiano, D; Amenga-Etego, L; Ghansah, A; Koram, K; Wilson, M; Enimil, A; Evans, J; Amodu, O; Olaniyan, S; Apinjoh, T; Mugri, R; Ndi, A; Ndila, C; Uyoga, S; Macharia, A; Peshu, N; Williams, T; Manjurano, A; Sepúlveda, N; Clark, T; Riley, E; Drakeley, C; Reyburn, H; Nyirongo, V; Kachala, D; Molyneux, M; Dunstan, S; Phu, N; Quyen, N; Thai, C; Hien, T; Manning, L; Laman, M; Siba, P; Karunajeewa, H; Allen, S; Allen, A; Davis, T; Michon, P; Mueller, I; Molloy, S; Campino, S; Kerasidou, A; Cornelius, V; Hart, L; Shah, S; Band, G; Spencer, C; Agbenyega, T; Achidi, E; Doumbo, O; Farrar, J; Marsh, K; Taylor, T; Kwiatkowski, D; MalariaGEN Consortium

Journal article

Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia

Abstract:: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is believed to confer protection against Plasmodium falciparum malaria, but the precise nature of the protective effecthas proved difficult to define as G6PD deficiency has multiple allelic variants with different effects in males and females, and it has heterogeneous effects on the clinical outcome of P. falciparum infection. Here we report an analysis of multiple allelic forms of G6PD deficiency in a large multi-centre case-control study o...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Clarke, G., Rockett, K., Kivinen, K., Hubbart, C., Jeffreys, A., Rowlands, K., Jallow, M., Conway, D., Bojang, K., Pinder, M., Usen, S., Sisay-Joof, F., Sirugo, G., Toure, O., Thera, M., Konate, S., Sissoko, S., Niangaly, A., Poudiougou, B., … Consortium, M. G. E. N. (2017). Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia. ELife, 6.

MLA Style

Clarke, G., et al. “Characterisation of the Opposing Effects of G6PD Deficiency on Cerebral Malaria and Severe Malarial Anaemia.” ELife, vol. 6, eLife Sciences Publications, 2017.

Chicago Style

Clarke, G, K Rockett, K Kivinen, C Hubbart, A Jeffreys, K Rowlands, M Jallow, et al. 2017. “Characterisation of the Opposing Effects of G6PD Deficiency on Cerebral Malaria and Severe Malarial Anaemia.” ELife 6.
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Publisher copy:: 10.7554/eLife.15085

Authors

+ Clarke, G More by this author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Sub department:

Human Genetics Wt Centre

Role:

Author

+ Rockett, K More by this author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Sub department:

Human Genetics Wt Centre

Role:

Author

+ Kivinen, K More by this author

Role:

Author

+ Hubbart, C More by this author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Sub department:

Human Genetics Wt Centre

Role:

Author

+ Jeffreys, A More by this author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Sub department:

Human Genetics Wt Centre

Role:

Author

More authors...

Funding

+ Medical Research Council More from this funder

Funding agency for:

Kwiatkowski, D

Grant:

G0600718

G0600230

G19/9

+ Wellcome Trust More from this funder

Funding agency for:

Spencer, C

Kwiatkowski, D

Grant:

097364/Z/11/Z

G0600718

G0600230

G19/9

090770/Z/09/Z

MalariaGEN Project 077383/Z/05/Z

077012/Z/05/Z

090532/Z/09/Z

+ European Commission More from this funder

Grant:

Europaid: SANTE/2004/078-607

+ Foundation for the National Institutes of Health More from this funder

Grant:

Bill

MelindaGatesFoundationGr

ChallengesinGlobalHealth566

Bibliographic Details

Publisher:: eLife Sciences Publications
Journal:: eLife More from this journal
Volume:: 6
Article number:: e15085
Publication date:: 2017-01-09
Acceptance date:: 2016-11-03
DOI:: 10.7554/eLife.15085
ISSN:: 2050-084X

Item Description

Language:: English
Keywords:: human

evolutionary biology

G6PD deficiency

genetic association

infectious disease

epidemiology

selection

genomics

global health
Pubs id:: pubs:670810
UUID:: uuid:444aa04a-3384-4bf7-9c75-8a7e7ff44394
Local pid:: pubs:670810
Source identifiers:: 670810
Deposit date:: 2017-01-26

Terms of use

Copyright holder:: Clarke et al
Notes:: Copyright © 2017 Clarke et al.
This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

Licence:: CC Attribution (CC BY)

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Journal article

Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia

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