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Journal article

Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes.

Abstract:

In fasting nondiabetic subjects, insulin is secreted in regular pulses every 12 to 15 minutes, but patients with non-insulin-dependent diabetes lack regular oscillatory insulin secretion. To investigate whether abnormal insulin oscillations are an early feature of diabetes, we studied 10 minimally glucose-intolerant first-degree relatives of patients with non-insulin-dependent diabetes and 10 controls matched for age and obesity. We performed a time-series analysis of fasting plasma insulin l...

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Publication status:
Published

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Publisher copy:
10.1056/nejm198805123181902

Authors


Journal:
The New England journal of medicine
Volume:
318
Issue:
19
Pages:
1225-1230
Publication date:
1988-05-05
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
URN:
uuid:4440d515-31d8-4d09-9c59-04e1b48a3b3c
Source identifiers:
72842
Local pid:
pubs:72842

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