- Abstract:
-
In fasting nondiabetic subjects, insulin is secreted in regular pulses every 12 to 15 minutes, but patients with non-insulin-dependent diabetes lack regular oscillatory insulin secretion. To investigate whether abnormal insulin oscillations are an early feature of diabetes, we studied 10 minimally glucose-intolerant first-degree relatives of patients with non-insulin-dependent diabetes and 10 controls matched for age and obesity. We performed a time-series analysis of fasting plasma insulin l...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1056/nejm198805123181902
-
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- Journal:
- The New England journal of medicine
- Volume:
- 318
- Issue:
- 19
- Pages:
- 1225-1230
- Publication date:
- 1988-05-05
- DOI:
- EISSN:
-
1533-4406
- ISSN:
-
0028-4793
- URN:
-
uuid:4440d515-31d8-4d09-9c59-04e1b48a3b3c
- Source identifiers:
-
72842
- Local pid:
- pubs:72842
- Language:
- English
- Keywords:
- Copyright date:
- 1988
Journal article
Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes.
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