- Abstract:
-
Invariant natural killer T (iNKT) cells are restricted by the non-polymorphic MHC class I-like protein, CD1d, and activated following presentation of lipid antigens bound to CD1d molecules. The prototypical iNKT cell agonist is α-galactosyl ceramide (α-GalCer). CD1d-mediated activation of iNKT cells by this molecule results in the rapid secretion of a range of pro-inflammatory (Th1) and regulatory (Th2) cytokines. Polarization of the cytokine response can be achieved by modifying the structur...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1021/cb2005017
-
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- Journal:
- ACS chemical biology
- Volume:
- 7
- Issue:
- 5
- Pages:
- 847-855
- Publication date:
- 2012-05-05
- DOI:
- EISSN:
-
1554-8937
- ISSN:
-
1554-8929
- URN:
-
uuid:443f561e-48d7-49f5-95aa-16b0e9216bfa
- Source identifiers:
-
264822
- Local pid:
- pubs:264822
- Copyright date:
- 2012
Journal article
Amide analogues of CD1d agonists modulate iNKT-cell-mediated cytokine production.
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