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Amide analogues of CD1d agonists modulate iNKT-cell-mediated cytokine production.

Abstract:

Invariant natural killer T (iNKT) cells are restricted by the non-polymorphic MHC class I-like protein, CD1d, and activated following presentation of lipid antigens bound to CD1d molecules. The prototypical iNKT cell agonist is α-galactosyl ceramide (α-GalCer). CD1d-mediated activation of iNKT cells by this molecule results in the rapid secretion of a range of pro-inflammatory (Th1) and regulatory (Th2) cytokines. Polarization of the cytokine response can be achieved by modifying the structur...

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Publication status:
Published

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Publisher copy:
10.1021/cb2005017

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Journal:
ACS chemical biology
Volume:
7
Issue:
5
Pages:
847-855
Publication date:
2012-05-05
DOI:
EISSN:
1554-8937
ISSN:
1554-8929
URN:
uuid:443f561e-48d7-49f5-95aa-16b0e9216bfa
Source identifiers:
264822
Local pid:
pubs:264822

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