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Multiple cross-reactive self-ligands for Borrelia burgdorferi-specific HLA-DR4-restricted T cells.

Abstract:

T cell recognition of self antigens is a key event in the pathogenesis of autoimmune diseases. To date, the initial events that trigger autoreactive T cells are unknown. The "molecular mimicry" hypothesis predicts that during an infection T cells that recognize both a microbial antigen and a related self peptide become activated and cause autoimmune disease. We have systematically examined the recognition of self antigens by HLA-DR4-restricted T cells specific for peptides of the outer surfac...

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Authors


Molinger, M More by this author
Schneider-Mergener, J More by this author
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Journal:
European journal of immunology
Volume:
30
Issue:
2
Pages:
448-457
Publication date:
2000-02-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:443ee38a-3fb3-42a4-ac9f-cd4a81596a9e
Source identifiers:
314744
Local pid:
pubs:314744

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