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Dicer-dependent turnover of intergenic transcripts from the human beta-globin gene cluster.

Abstract:

The widespread occurrence of intergenic transcription in eukaryotes is increasingly evident. Intergenic transcription in the beta-globin gene cluster has been described in murine and human cells, and models for a role in gene and chromatin activation have been proposed. In this study, we analyze intergenic transcription and the chromatin state throughout the human beta-globin gene cluster and find that the data are not consistent with such activation-linked models. Thus, intergenic transcript...

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Publication status:
Published

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Authors


Haussecker, D More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Molecular and cellular biology
Volume:
25
Issue:
21
Pages:
9724-9733
Publication date:
2005-11-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:443649b4-7511-4a36-baf4-bd040fb8d223
Source identifiers:
30892
Local pid:
pubs:30892

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