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Journal article

Cell-extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells

Abstract:

Despite the well-established cell-intrinsic role of epigenetic factors in normal and malignant hematopoiesis, their cell-extrinsic role remains largely unexplored. Herein we investigated the hematopoietic impact of inactivating Ezh2, a key component of polycomb repressive complex 2 (PRC2), in the fetal liver (FL) vascular niche. Hematopoietic specific (Vav-iCre) Ezh2-inactivation enhanced FL hematopoietic stem cell (HSC) expansion with normal FL erythropoiesis. In contrast, endothelium (Tie2-...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1182/blood-2017-10-811455

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Clinical Laboratory Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Clinical Laboratory Sciences
Role:
Author
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Grant:
MR/L006340/1
MC_UU_12009
MC_UU_12025
G0902418
MC_UU_12009/5
Publisher:
American Society of Hematology Publisher's website
Journal:
Blood Journal website
Volume:
131
Issue:
20
Pages:
2223-2234
Publication date:
2018-05-17
Acceptance date:
2018-03-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Pubs id:
pubs:855790
URN:
uri:44324994-52da-4b1c-b00a-7f4df1210d42
UUID:
uuid:44324994-52da-4b1c-b00a-7f4df1210d42
Local pid:
pubs:855790

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