Journal article icon

Journal article

Safety, immunogenicity and efficacy of a pre-erythrocytic malaria candidate vaccine, ICC-1132 formulated in Seppic ISA 720.

Abstract:

ICC-1132, a recombinant virus-like particle comprising of a modified hepatitis B core protein with a B cell (NANP) and two T cell epitopes of Plasmodium falciparum circumsporozoite protein (CSP), was administered i.m. as a single 50 microg dose in Seppic ISA 720 to 11 volunteers. Local reactogenicity and systemic side effects were acceptable with the predominant finding being mild pain at the injection site. This regimen induced anti-NANP antibodies in 10/11 and modest T cell responses. There...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
Vaccine
Volume:
23
Issue:
7
Pages:
857-864
Publication date:
2005-01-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:44302b02-17d0-4ba2-802b-98fdbd021118
Source identifiers:
32937
Local pid:
pubs:32937

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP